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Beloved

"You whom I love" or "Dear friends"

let us cleanse ourselves of all defilement of flesh and spirit

Here Paul is saying to stay away from any form of sin that would affect one's relationship with God.

of all defilement of flesh and spirit

"of all things in our body and spirit that make us unacceptable to God"

Let us perfect holiness

"Let us do all we can to be perfectly holy"

in the fear of God

"out of deep respect for God" or "because we fear God"