en_tn/luk/11/50.md

This generation, then, will be held responsible for all the blood of the prophets shed

The people to whom Jesus is speaking will be held responsible for the murder of the prophets by their ancestors. Alternate translation: "Therefore, God will hold this generation responsible for all the deaths of the prophets that people have killed" (See: rc://en/ta/man/jit/figs-metonymy and rc://en/ta/man/jit/figs-activepassive)

the blood of the prophets shed

The "blood ... shed" refers to the blood spilled when they were killed. Alternate translation: "the murder of the prophets" (See: rc://en/ta/man/jit/figs-metonymy)

since the foundation of the world

The author speaks of the world as if it were a building set on a foundation. Alternate translation: "since the creation of the world" or "since God created the world" (See: rc://en/ta/man/jit/figs-metaphor)