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we should always give thanks

"we should continually give thanks"

we should

Here "we" refers to Paul, Silvanus, and Timothy.

brothers loved by the Lord

This can be stated in active form. Alternate translation: "for the Lord loves you, brothers" (See: rc://en/ta/man/jit/figs-activepassive)

brothers

"brothers and sisters"

as the firstfruits to be saved through the sanctification by the Spirit and belief in the truth

"to be among the first people who believe what is true, whom God has saved and set apart for himself by his Spirit"