# General Information: Paul begins to give his final instructions to the church in Thessalonica. # brothers Here "brothers" means fellow believers. # to acknowledge those who labor "to esteem and appreciate those who are involved in leading" # who are over you in the Lord This refers to people God appointed to serve as leaders of the local group of believers. # regard them highly in love because of their work Paul exhorts the believers to love and esteem their church leaders.