# we should always give thanks

"we should continually give thanks"

# we should

Here "we" refers to Paul, Silvanus, and Timothy.

# brothers loved by the Lord

"for the Lord loves you, brothers" 

# as the firstfruits to be saved through the sanctification by the Spirit and belief in the truth

"to be among the first people who believe what is true, whom God has saved and set apart for himself by his Spirit"