# Nation, sinners

"Nation of sinners"

# a people weighed down with iniquity

"their sin is like a heavy bag on their shoulders that makes it hard for them to walk" 

# offspring of evildoers

"people who do the same evil they see others doing" 

# act corruptly

do evil deeds

# They have abandoned Yahweh

"They have gone away from Yahweh"

# have despised

"have refused to obey" or "have refused to respect"

# Israel

Judah is part of what had been the nation of Israel.

# they have estranged themselves from him

Though at one time they were friends, they now treat him as though they do not know him.