Cain was a son of the first man, Adam, and the first woman, Eve. He was jealous of his brother and murdered him. Readers may not know who Cain was if they have not read Genesis. It may help them if you explain this to them.
The verb "to know" is used in two different ways in this chapter. Sometimes it is used about knowing a fact, as in 3:2, 3:5, and 3:19. Sometimes it means to experience and understand someone or something, as in 3:1, 3:6, 3:16, and 3:20. Some languages have different words for these different meanings.
Many scholars believe this is about remaining in God's will and is not about being saved. (See: [[rc://en/tw/dict/bible/kt/eternity]] and [[rc://en/tw/dict/bible/kt/save]])