# Awake, awake, stand up, Jerusalem
"Awake, awake, stand up, you people of Jerusalem"
# you who have drunk out of the hand of Yahweh ... from the cup of staggering
Yahweh speaks of having punished his people as if he had forced them to drink from a bowl that was filled with his anger. And when they drank from the bowl of his anger, they staggered as if they had drank a lot of wine.
# down to the dregs
"down to the very bottom"
# staggering
not walking straight, or stumbling while walking