The word "filthiness" refers to things that the people had used to worship other gods. The narrator speaks of these things making the temple unacceptable to Yahweh as if they were physically dirty. Alternate translation: "remove the things that defile the holy place" or "remove the things that make the holy place unacceptable to Yahweh" (See: [[rc://en/ta/man/jit/figs-metaphor]])