# With every prayer and request, pray at all times in the Spirit

"Pray at all times in the Spirit as you pray and make specific requests"

# To this end

"For this reason" or "Keeping this in mind." This refers to the attitude of taking God's armor.

# be watching with all perseverance as you offer prayers for all God's holy people

"be watching, and even when it is difficult, keep praying for all the believers "